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Novartis Research and Development (R&D)

Novartis Research and Development (R&D)

Publications

2009

  • Su, Xun-Cheng; Ozawa, Kiyoshi; Yagi, Hiromasa; Lim, Siew P.; Wen, Daying; Ekonomiuk, Dariusz; Huang, Danzhi; Keller, Thomas H.; Sonntag, Sebastian; Caflisch, Amedeo; Vasudevan, Subhash G.; Otting, Gottfried.   NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease.    FEBS Journal  (2009),  276(15),  4244-4255.
  • Fink, Katja; Ng, Cedrig; Nkenfou, Celine; Vasudevan, Subhash G.; van Rooijen, Nico; Schul, Wouter.   Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control.    European Journal of Immunology  (2009),  39(10),  2809-2821.
  • Low, Kai Leng; Rao, P. S. Srinivasa; Shui, Guanghou; Bendt, Anne K.; Pethe, Kevin; Dick, Thomas; Wenk, Markus R.   Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guerin.    Journal of Bacteriology  (2009),  191(16),  5037-5043.
  • Wang, Qing-Yin; Patel, Sejal J.; Vangrevelinghe, Eric; Xu, Hao Ying; Rao, Ranga; Jaber, Deana; Schul, Wouter; Gu, Feng; Heudi, Olivier; Ma, Ngai Ling; Poh, Mee Kian; Phong, Wai Yee; Keller, Thomas H.; Jacoby, Edgar; Vasudevan, Subhash G.   A small-molecule dengue virus entry inhibitor.    Antimicrobial Agents and Chemotherapy  (2009),  53(5),  1823-1831.
  • Rothwell, Christopher; Le Breton, Aude; Ng, Chuan Young; Lim, Joanne Y. H.; Liu, Wei; Vasudevan, Subhash; Labow, Mark; Gu, Feng; Gaither, L. Alex.   Cholesterol biosynthesis modulation regulates dengue viral replication.    Virology  (2009),  389(1-2),  8-19.
  • Schreiber, Mark; Res, Ivica; Matter, Alex.   Protein kinases as antibacterial targets.    Current Opinion in Cell Biology  (2009),
  • Rajamanonmani, Ravikumar; Nkenfou, Celine; Clancy, Paula; Yau, Yin Hoe; Shochat, Susana Geifman; Sukupolvi-Petty, Soila; Schul, Wouter; Diamond, Michael S.; Vasudevan, Subhash G.; Lescar, Julien.   On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes.    Journal of General Virology  (2009),  90(4),  799-809.
  • Schreiber, Mark J.; Holmes, Edward C.; Ong, Swee Hoe; Soh, Harold S. H.; Liu, Wei; Tanner, Lukas; Aw, Pauline P. K.; Tan, Hwee Cheng; Ng, Lee Ching; Leo, Yee Sin; Low, Jenny G. H.; Ong, Adrian; Ooi, Eng Eong; Vasudevan, Subhash G.; Hibberd, Martin L.   Genomic epidemiology of a dengue virus epidemic in urban Singapore.    Journal of Virology  (2009),  83(9),  4163-4173.
  • Ekonomiuk, Dariusz; Su, Xun-Cheng; Ozawa, Kiyoshi; Bodenreider, Christophe; Lim, Siew Pheng; Yin, Zheng; Keller, Thomas H.; Beer, David; Patel, Viral; Otting, Gottfried; Caflisch, Amedeo; Huang, Danzhi.   Discovery of a non-peptidic inhibitor of West Nile virus NS3 protease by high-throughput docking.    PLoS Neglected Tropical Diseases  (2009),  3(1),  No pp. given.  CODEN: PNTDAM  ISSN:1935-2735.
  • Kim, Pilho; Kang, Sunhee; Boshoff, Helena I.; Jiricek, Jan; Collins, Margaret; Singh, Ramandeep; Manjunatha, Ujjini H.; Niyomrattanakit, Pornwaratt; Zhang, Liang; Goodwin, Michael; Dick, Thomas; Keller, Thomas H.; Dowd, Cynthia S.; Barry, Clifton E.   Structure-Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure-Activity Relationships.    Journal of Medicinal Chemistry  (2009),  52(5),  1329-1344.
  • Kim, Pilho; Zhang, Liang; Manjunatha, Ujjini H.; Singh, Ramandeep; Patel, Sejal; Jiricek, Jan; Keller, Thomas H.; Boshoff, Helena I.; Barry, Clifton E., III; Dowd, Cynthia S.   Structure-Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles.    Journal of Medicinal Chemistry  (2009),  52(5),  1317-1328.

 

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Neglected diseases

Neglected diseases

We aim to discover new treatments and prevention methods for major tropical diseases. Learn more about the main tropical diseases:

Access to Medicines

Access to Medicines

In developing countries, access to medicines is limited - and we want to be a leader and partner in finding and implementing solutions to help close the access gap.

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